"There is no doubt that this college is destined to have influence on the future of Indian womanhood in this Presidency. How anxiously and hopefully I wait to see the assurance that the influence will be for good"-Miss.Dorothy De La hey ,Founder Principal

The College has been blessed from its inception with an illustrious line of Principals:
| Miss Dorothy De La Hey | 1914-1936 |
| Miss K.Myers | 1936-1946 |
| Mrs.N.Ramamoorthy | 1946-1950 |
| Mrs. M.Lakshmi Ammal | 1950-1950 |
| Miss. V.Koman | 1950-1955 |
| Miss A.R.Irawathy | 1955-1970 |
| Mrs. N.Shanmugasundaram | 1970-1972 |
| Miss K.Jegathambal | 1972-1977 |
| Mrs. Inayathunnisa Munaver | 1977-1980 |
| Miss. Y. Sorojini Devi | 1980-1981 |
| Dr.(Tmt)P.B.Raja Rajeswari | 1981-1988 |
| Dr.(Tmt)Nirmala Thyagarajan | 1988-1992 & 1995-1996 |
| Dr.(Miss)V.A.Vasantha | 1992-1995 |
| Dr.Anne Srinivasan | 1996-1999 |
| Tmt.K.Kumari Meenakshi | 1999-2000 |
| Dr.(Tmt.)Primula Newsam | 2000-2001 |
| Tmt.D.Padmini | 2001-2003 |
| Dr.(Tmt.)P.T.Rajalakshmi | 2003-2004 |
| Tmt.Malini Subramanian | 2004-2005 |
| Tmt.Eugenie Pinto | 2005-todate |
Our Principals have helped the growth of our college through all periods of stress and strain and have inculcated sound values and high standards in the students.
Queen Mary's College has always been accredited with many a first. It was not only the first Government College for women but also the first Government College for Women to be granted autonomous status in 1987 and to be accredited with 4 stars by NAAC in 1999.It is the first Government Women's College to offer Ph.D programmes in Botany & Indian Music from 2006 onwards.
Today we can say with our founder Principal Miss Dorothy De La Hey,wrote in 1917, "Here we are a large community of various castes and creeds speaking various tongues. Let each member of the community preserve her own individuality and yet draw from her studies,from her games,from intercourses with her companions,a widening comprehension of the meaning and the value of life a deepening resolution to make her life one of usefulness,of service and of help".
.INDIA TODAY Special issue June 5 2006:
QMC Rated 19th Overall rating for arts courses
Statewise rating : QueenMary'sCollege -4th rank-Arts
5th rank-Science
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